Myrothecine A

Overview

Myrothecine A is a trichothecene mycotoxin found in M. roridum . Myrothecine A induces apoptosis , promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK , increases Bax and cleaved caspase-3 , -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC 50 s of 95, 70, 60, and 25 µM, respectively.

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-N8508
• CAS No.: 910292-40-9
• Molecular Formula: C29H38O10
• Molecular Weight: 546.61
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source