Garcinoic acid

Overview

Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2 , porcine α-amylase , Saccharomyces cerevisiae α-glucosidase and human DNA polymerase β ( IC 50 =11 μM), as well as activates human PXR . Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1 , and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > COX | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Amylases | Products > Signaling Pathways > β-glucuronidase | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Pregnane X Receptor (PXR)

Product Information

• Catalog No.: HY-N9454
• CAS No.: 91893-83-3
• Molecular Formula: C27H38O4
• Molecular Weight: 426.59
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source