Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin ( HY-N0783 ), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca( 2+ )] i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury.
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