Nebentan

Overview

Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ET A receptor antagonist through the modification of Bosentan ( HY-A0013 ). Nebentan inhibits [ 125 I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K i of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.

Application

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Product Information

• Catalog No.: HY-106994
• CAS No.: 403604-85-3
• Molecular Formula: C24H21N5O5S
• Molecular Weight: 491.52
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

Source

Original product source