MPP+ iodide

Overview

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).

Application

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Product Information

• Catalog No.: HY-W008719
• CAS No.: 36913-39-0
• Molecular Formula: C12H12IN
• Molecular Weight: 297.14
• Purity: 99.96%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: 2.5 mg/mL (8.41 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source