Nitrefazole

Overview

Nitrefazole (EMD-15700) is an aldehyde dehydrogenase ( ALDH ) inhibitor. Nitrefazole specifically inhibits human liver ALDH I and human erythrocyte ALDH isozymes, but does not alter the activity of human liver ALDH II or human placental ALDH. Nitrefazole effectively promotes exosome secretion in prostate cancer cells by increasing the levels of Alix , nSMase2 , Rab27a and p-ERK . Nitrefazole can be used in studies related to prostate cancer .

Application

Products | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Aldehyde Dehydrogenase (ALDH) | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-107030
• CAS No.: 21721-92-6
• Molecular Formula: C10H8N4O4
• Molecular Weight: 248.19
• Purity: 99.44%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution
• Availability: In-stock

Source

Original product source