UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 ( MMP-3 ) with an IC 50 of 5.9 nM. UK 356618 is less potent against MMP-1 , MMP-2 , MMP-9 , MMP-13 and MMP-14 compared with MMP-3 .
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