Phorone

Overview

Phorone (Diisopropylidene acetone) is a glutathione ( GSH ) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding ( Glutathione S-transferase ) ( K m = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Glutathione S-transferase

Product Information

• Catalog No.: HY-W017785
• CAS No.: 504-20-1
• Molecular Formula: C9H14O
• Molecular Weight: 138.21
• Purity: 99.79%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source