HDGFRP2/PSIP1-IN-1

Overview

HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 ( HDGFRP2 ) and its homologous protein PSIP1 , hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a K d value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a K d value of 27 μM; meanwhile, it has a K d value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily.

Application

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Product Information

• Catalog No.: HY-W023758
• CAS No.: 166196-54-9
• Molecular Formula: C8H6BrN3
• Molecular Weight: 224.06
• Purity: 99.50%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (22.32 mM); Clear solution
• Availability: In-stock

Source

Original product source