Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii . Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin , fat browning-related genes, and hypothalamic BDNF-TrkB signaling.
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