OR-1855, an active metabolite of Levosimendan ( HY-14286 ), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK , ERK1/2 , c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation.
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