iST2-1

Overview

iST2-1 is an Stimulation-2 (ST2) inhibitor with an IC 50 value of 46.65 μM, blocks interaction between ST2 and IL-33 , inhibits downstream signaling. iST2-1 functions as an immunomodulator, reduces proliferation of CD4 + and CD8 + T cells, increases regulatory T cell populations, reduces IFN-γ + CD4 + T cell populations, increases Foxp3 + CD4 + regulatory T cell populations in the gastrointestinal tract. iST2-1 reduces plasma soluble ST2 and IFN-γ levels, reduces graft-versus-host disease scores, improves survival in graft-versus-host disease animal models, preserves graft-versus-tumor effect. iST2-1 can be used for the research of graft-versus-host disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-W060417
• CAS No.: 1019158-02-1
• Molecular Formula: C22H22N2O4
• Molecular Weight: 378.42
• Purity: 99.58%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (13.21 mM); Clear solution
• Availability: In-stock

Source

Original product source