L6H21

Overview

L6H21, a Chalcone ( HY-121054 ) derivative, is an orally active, potent and specific myeloid differentiation 2 ( MD-2 ) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K D value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC 50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research.

Application

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Product Information

• Catalog No.: HY-W082785A
• CAS No.: 24533-47-9
• Molecular Formula: C18H18O4
• Molecular Weight: 298.34
• Purity: 99.19%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (8.38 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source