LLY-283

Overview

LLY-283, a chemical probe, is a potent, selective and oral protein arginine methyltransferase 5 ( PRMT5 ) inhibitor, with an IC 50 of 22 nM and a K d of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-107777
• CAS No.: 2040291-27-6
• Molecular Formula: C17H18N4O4
• Molecular Weight: 342.35
• Purity: 98.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (6.08 mM); Clear solution
• Availability: In-stock

Source

Original product source